From January 2021 many browsers will no longer support Flash technology and some games such as The Binding of Isaac may not work.
Solutions are being studied to allow Flash games being playable again on browser. If your game doesn't work you can try one of the similar games on this page.
The Binding of IsaacAuthor : Newgrounds - 55 390 plays
Here is a unique opportunity to discover the famous game The Binding of Isaac through this demo version will allow you to browse the first two levels of the game freely. Follow the adventure of the young Isaac who fled the family home by a strange door of his room. His mother, completely schizophrenic, hearing voices and wanted to sacrifice his son with a butcher knife.